I am using it with windows 2000 (for which the setup is a little messy and none of the distributed software installs) and a Canon S100. I use ULead's PhotoExplorer 6.0 (freeware) for printing 4 pics on a 8x11.
The print depends heavily on the paper being used; with the best quality print being gained from the Canon Photo Pro paper that comes with the printer. The print is indistinguishable from a photo ! Especially if you do some software trickery of resampling the image to a higher resolution.
One noticeable problem is that the pictures are a little washed out. The Photo Optimizer setting makes the picture a little darker (puts more black) and gives the illusion of greater detail.
The printer is also very slow ! But that doesnt really bother me.
Otherwise the printer is VERY economical to run especially with Best Buy's buy 2 cartridges get 3rd free !