The buttons to the left of the keyboard are not very useful. The cursor needs to be moved over a window before the keyboard wheel can be used to scoll the window. Instead of doing a maneuver with the mouse and the keyboard, one can easily accomplish the same task with arrow keys. Below the keyboard wheel button is a back button (not configurable, works only with Internet Explorer) and a Go button (which can only launch web pages). The rest of the progammable keys have more option as to what it can do, including multimedia/internet functions, launching folders, menus, and applications.
Speaking of programmability, the F1-F12 keys by default come with email functionalities, such as new, reply, forward, and send. If this is an inconvenience, these keys can be de-programmed to act like the F1-F12 keys by assigning them the "transparent pass-through" function. The Go button is easy to press by mistake when holding the keyboard by its left side, so in addition to the "transparent pass-through" function, a "do nothing" function for the go button would have been nice. The F-lock key works like the caps lock key, except when the F-lock is on, it forces the F1-F12 keys to behave like F1-F12 keys instead of like programmed keys. There is no option to have the F-lock turned on by default upon Windows startup.